By using .me domains you could create nice domain hacks, so .me could become extremely popular for advertising campaigns and other marketing stuff. You could also register domain hacks like extre.me. Unfortunately the best words may already have been taken by someone, but my guess is that many of the undeveloped domains will drop again in the next two years, so by keeping an eye open on the dropping names could give you a really nice domain.
Even if you can’t find an already existing word as domain under the .me TLD you can still make up new words, and you can also of course register your .com domain as a .me too and use it for a community web site for your customers .
The statistics from Xavier Media Whois shows that since the release of the .me TLD the number of pages hosted at .me domains has just increase to 3,190,000 pages today: